Human Microbiome
Evaluation of human microbiome composition and activity and its inter-connections with health/disease or other factors
Main research topics
Molecular mechanisms linking microbiome and disease in adults and children
Evaluation of the inter-connections between human microbiome (gut, oral, skin) composition and activities and host health, through observational studies, clinical trials or animal-model studies. This includes (but is not limited to): relationships between human microbiome and food and non-food allergies, mental disorders (autism spectrum disorder, epilepsy), obesity, metabolic syndrome and diabetes, inflammatory bowel disease, cardiovascular diseases, hepatic diseases (viral infections, cirrhosis, hepatocellular carcinoma, liver steatosis), dermatitis and eczema, periodontitis and other oral diseases. Interactions between gut microbiome and immune system. Effect of environmental pollution on human microbiome.
Diet and microbiome
Unveiling the influence of dietary patterns (e.g. Mediterranean, ketogenic or vegetarian/vegan diets), specific dietary components (e.g. fibre, lipids) or supplements (pre-, pro- and post-biotic) on the human microbiome through observational studies, clinical trials or animal-model studies. Exploiting the possibility of modulating the microbiome through dietary interventions for the prevention/treatment of specific pathologies. Evaluating microbiome composition in individuals with eating disorders or secondary malnutrition.
Gut-brain axis
Exploring the effect of microbial neuroactive metabolites on brain function and the mechanisms of intestinal permeability linking gut microbiome and the enteric nervous system.